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Hy 13207 Pfk 158 Medchemexpress Hy 12203 Roscovitine Medchemexpress Hy 30237 Rotenone Merck R8875 Rsl 3 Merck Sml2234 Tnfα Invivogen Rcyc Htnfa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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<t>Roscovitine</t> alleviated HG-induced islet β cell injury by inhibiting Cdk5 expression. (A–C) Protein expression levels of Cdk5, p35/25, p62, and Beclin1 in Min6 cells. (D) Insulin concentration in the culture supernatant of Min6 cells was measured using ELISA. (E–G) Protein expression levels of Cdk5, p35/25, p62, and Beclin1 in Min6 cells. (H–K) Immunofluorescence staining of Cdk5, p35/25, and insulin in Min6 cells. (L) Insulin concentrations in the culture supernatant of Min6 cells were measured using ELISA. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG+DMSO group.
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Roscovitine alleviated HG-induced islet β cell injury by inhibiting Cdk5 expression. (A–C) Protein expression levels of Cdk5, p35/25, p62, and Beclin1 in Min6 cells. (D) Insulin concentration in the culture supernatant of Min6 cells was measured using ELISA. (E–G) Protein expression levels of Cdk5, p35/25, p62, and Beclin1 in Min6 cells. (H–K) Immunofluorescence staining of Cdk5, p35/25, and insulin in Min6 cells. (L) Insulin concentrations in the culture supernatant of Min6 cells were measured using ELISA. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG+DMSO group.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage

doi: 10.3389/fcell.2025.1613081

Figure Lengend Snippet: Roscovitine alleviated HG-induced islet β cell injury by inhibiting Cdk5 expression. (A–C) Protein expression levels of Cdk5, p35/25, p62, and Beclin1 in Min6 cells. (D) Insulin concentration in the culture supernatant of Min6 cells was measured using ELISA. (E–G) Protein expression levels of Cdk5, p35/25, p62, and Beclin1 in Min6 cells. (H–K) Immunofluorescence staining of Cdk5, p35/25, and insulin in Min6 cells. (L) Insulin concentrations in the culture supernatant of Min6 cells were measured using ELISA. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG+DMSO group.

Article Snippet: Roscovitine was purchased from Dalian Meilun Biotechnology Co. Ltd. K252a (HY-N6732) was obtained from MedChemExpress.

Techniques: Expressing, Concentration Assay, Enzyme-linked Immunosorbent Assay, Immunofluorescence, Staining

Roscovitine counteracted the HG-induced reduction in NGF and Sirt1 expression in islet β cells. (A–F) Immunohistochemical and immunofluorescence staining and statistical analysis of NGF and Sirt1 in human pancreatic tissues. * P < 0.05 vs. ND group. (G–I) Immunofluorescence staining was used to detect Sirt1 and NGF expression in Min6 cells. (J,K) NGF and Sirt1 protein expression levels in Min6 cells. (L,M) NGF and Sirt1 protein expression levels in Min6 cells. (N) Immunofluorescence staining of Sirt1 and NGF in Min6 cells. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG+DMSO group.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage

doi: 10.3389/fcell.2025.1613081

Figure Lengend Snippet: Roscovitine counteracted the HG-induced reduction in NGF and Sirt1 expression in islet β cells. (A–F) Immunohistochemical and immunofluorescence staining and statistical analysis of NGF and Sirt1 in human pancreatic tissues. * P < 0.05 vs. ND group. (G–I) Immunofluorescence staining was used to detect Sirt1 and NGF expression in Min6 cells. (J,K) NGF and Sirt1 protein expression levels in Min6 cells. (L,M) NGF and Sirt1 protein expression levels in Min6 cells. (N) Immunofluorescence staining of Sirt1 and NGF in Min6 cells. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG+DMSO group.

Article Snippet: Roscovitine was purchased from Dalian Meilun Biotechnology Co. Ltd. K252a (HY-N6732) was obtained from MedChemExpress.

Techniques: Expressing, Immunohistochemical staining, Immunofluorescence, Staining

NGF knockdown attenuated the protective effect of roscovitine on islet β cells. (A,B) NGF protein expression level in Min6 cells. (C–E) Protein expression levels of NGF, Sirt1, p62, and Beclin1 in Min6 cells. (F) NGF and Sirt1 mRNA levels were analyzed via Rt-RCR. (G) Immunofluorescence staining of LC3B and LAMP1. (H) Insulin concentration in the culture supernatant of Min6 cells was measured using ELISA. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG group. & P < 0.05 vs. HG + roscovitine group.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage

doi: 10.3389/fcell.2025.1613081

Figure Lengend Snippet: NGF knockdown attenuated the protective effect of roscovitine on islet β cells. (A,B) NGF protein expression level in Min6 cells. (C–E) Protein expression levels of NGF, Sirt1, p62, and Beclin1 in Min6 cells. (F) NGF and Sirt1 mRNA levels were analyzed via Rt-RCR. (G) Immunofluorescence staining of LC3B and LAMP1. (H) Insulin concentration in the culture supernatant of Min6 cells was measured using ELISA. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG group. & P < 0.05 vs. HG + roscovitine group.

Article Snippet: Roscovitine was purchased from Dalian Meilun Biotechnology Co. Ltd. K252a (HY-N6732) was obtained from MedChemExpress.

Techniques: Knockdown, Expressing, Immunofluorescence, Staining, Concentration Assay, Enzyme-linked Immunosorbent Assay

NGF overexpression alleviated autophagy impairment of islet β cells induced by HG. (A,B) NGF protein expression levels in Min6 cells. (C–E) Protein expression levels of NGF, Sirt1, Beclin1, and p62 in Min6 cells. (F) NGF and Sirt1 mRNA levels were analyzed via Rt-RCR. (G) Immunofluorescence staining of LC3B and LAMP1. (H) Insulin concentration in the culture supernatant of Min6 cells was measured using ELISA. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG group. & P < 0.05, vs. HG + roscovitine group.

Journal: Frontiers in Cell and Developmental Biology

Article Title: Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage

doi: 10.3389/fcell.2025.1613081

Figure Lengend Snippet: NGF overexpression alleviated autophagy impairment of islet β cells induced by HG. (A,B) NGF protein expression levels in Min6 cells. (C–E) Protein expression levels of NGF, Sirt1, Beclin1, and p62 in Min6 cells. (F) NGF and Sirt1 mRNA levels were analyzed via Rt-RCR. (G) Immunofluorescence staining of LC3B and LAMP1. (H) Insulin concentration in the culture supernatant of Min6 cells was measured using ELISA. * P < 0.05 vs. Ctrl group. # P < 0.05 vs. HG group. & P < 0.05, vs. HG + roscovitine group.

Article Snippet: Roscovitine was purchased from Dalian Meilun Biotechnology Co. Ltd. K252a (HY-N6732) was obtained from MedChemExpress.

Techniques: Over Expression, Expressing, Immunofluorescence, Staining, Concentration Assay, Enzyme-linked Immunosorbent Assay